Nateglinide is an anti diabetic drug. Nateglinide fast dissolving tablet have been prepared by direct compression method. Effect of superdisintegrants (such as crosscarmellose sodium, sodium starch glycolate and crospovidone) on wetting time, disintegration time, drug content, in-vitro release and stability parameters has been studied. Disintegration time and dissolution parameters which increase in case of combination of croscarmellose sodium and sodium starch glycolate. Stability studies indicated that tablets containing super disintegrants were sensitive to high humidity conditions. It was concluded that the faster disintegration of crospovidone tablets may attributed to its rapid capillary activity and pronounced hydration with little tendency to gel formation.
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